How Changes to Intestinal Bacteria Affect Depressive-Like Behavior in Mice?
- Depression is a mental disorder that causes a constant feeling of sadness and loss of interest.
- Depression is the leading cause of disability worldwide.
- Recent studies show that mood disorders are associated with the changes of the intestinal bacteria.
- Mice were exposed to mild stressors and displayed phenotypic alterations.
- These phenotypic alterations could be transferred to a naïve recipient mice by fecal microbiota transplantation.
- The cellular and behavioral changes observed in the recipient mice were accompanied by a decrease of some neural signaling.
- The negative effects of the transferred microbiota were reduced by enhancing the neural signaling or by complementation with of a strain of good bacteria.
- The findings provide evidence about the relationship between chronic stress, diet, and intestinal bacteria and how it contributes to despair behavior via neural signaling.
Chevalier, G., Siopi, E., Guenin-Macé, L. et al. Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system. Nat Commun 11, 6363 (2020). https://doi.org/10.1038/s41467-020-19931-2
Research Summary: Role of Intestinal Bacteria in Gliadin-Induced Changes in Intestinal Mucosa: Study in Germ-Free Rats
ABSTRACT Background and Aims Celiac disease (CD) is a chronic inflammatory disorder of the small intestine that is induced by dietary wheat gluten proteins (gliadins) in genetically predisposed individuals. The overgrowth of potentially pathogenic bacteria and infections has been suggested to contribute to CD pathogenesis. We aimed to study the effects of gliadin and various … Continue reading
Research Highlights: How Changes to Intestinal Bacteria Affect Depressive-Like Behavior in Mice?
Original Article: https://doi.org/10.1038/s41467-020-19931-2 Depression is a mental disorder that causes a constant feeling of sadness and loss of interest. Depression is the leading cause of disability worldwide. Recent studies show that mood disorders are associated with the changes of the intestinal bacteria. Mice were exposed to mild stressors and displayed phenotypic alterations. These phenotypic alterations … Continue reading
Research Summary: Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Abstract Adult-onset hearing loss is very common, but we know little about the underlying molecular pathogenesis impeding the development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response (ABR). We … Continue reading
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