Research Highlights: How Changes to Intestinal Bacteria Affect Depressive-Like Behavior in Mice?


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Original Article:

  • Depression is a mental disorder that causes a constant feeling of sadness and loss of interest.
  • Depression is the leading cause of disability worldwide.
  • Recent studies show that mood disorders are associated with the changes of the intestinal bacteria.
  • Mice were exposed to mild stressors and displayed phenotypic alterations.
  • These phenotypic alterations could be transferred to a naïve recipient mice by fecal microbiota transplantation.
  • The cellular and behavioral changes observed in the recipient mice were accompanied by a decrease of some neural signaling.
  • The negative effects of the transferred microbiota were reduced by enhancing the neural signaling or by complementation with of a strain of good bacteria.
  • The findings provide evidence about the relationship between chronic stress, diet, and intestinal bacteria and how it contributes to despair behavior via neural signaling.


Chevalier, G., Siopi, E., Guenin-Macé, L. et al. Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system. Nat Commun 11, 6363 (2020).

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