Research Highlights: Cordyceps mushroom can produce more cordycepin on edible Japanese rhinoceros beetle

By Gombe at Japanese Wikipedia – Own work by the original uploader (Original text: Gombe撮影), CC BY-SA 3.0,

Cordyceps mushroom can produce more cordycepin on edible Japanese rhinoceros beetle

  • Cordycepin is a compound that can be extracted from Cordyceps mushroom.
  • Cordycepin has been found to be toxic on some leukemic cells.
  • Cordyceps mushroom usually grows from an insect.
  • Researchers used six edible insects as substrate to explore an optimized condition of Cordyceps cultivation for a more improved cordycepin production.
  • The highest cordycepin production was found using Japanese rhinoceros beetle.
  • Insect fat was found to be an important factor for the production of cordycepin.
  • Data suggested that as oleic acid increases, cordycepin production also increases.
  • Cns1 and cns2 are genes associated with the production of cordycepin, and were found to have high genetic activities in Cordyceps grown on Japanese rhinoceros beetle than on other insects used.


Cordyceps mushroom with increased cordycepin content by the cultivation on edible insects, Frontiers in Microbiology (2022). DOI: 10.3389/fmicb.2022.1017576.


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