Research Highlights: COVID-19 Infection Can Boost Common Seasonal Human Coronavirus Antibodies
- The COVID-19 virus has quickly spread within the human population.
- The COVID-19 virus is a new type of coronavirus.
- However, humans had been previously exposed to common seasonal human coronavirus before the COVID-19 pandemic.
- Common human coronaviruses usually cause mild/moderate upper-respiratory tract diseases such as the common cold.
- Researchers quantified levels of antibodies induced by COVID-19 virus and antibodies induced by the common seasonal human coronavirus.
- Samples were collected from 431 individuals before the COVID-19 pandemic.
- Researchers then quantified pre-pandemic antibody levels from another group of 251 individuals who became infected with the COVID-19 virus.
- Finally, both COVID-19 and common seasonal human coronavirus antibodies were measure in hospitalized COVID-19 patients.
- Data show that most individuals possessed common seasonal human coronavirus antibodies before the COVID-19 pandemic.
- Researchers determined that about 20 percent of these individuals possessed non-neutralizing antibodies that cross-reacted with the COVID-19 virus spike and proteins.
- The non-neutralizing antibodies do not seem to protect individual against the COVID-19 virus.
- The non-neutralizing antibodies were boosted upon COVID-19 viral infection.
Research Article: Casting a Wide Net to Fight Coronaviruses
Date Published: October 6, 2005 Publisher: Public Library of Science Author(s): unknown Abstract: None Partial Text: Viewed under a microscope, the coronavirus appears almost beautiful, thanks to the halo-like crown formed by its surface proteins. (“Corona” means “crown” in Latin.) Aesthetics aside, this genus of viruses is responsible for a wide range of animal and … Continue reading
Research Article: A Leaderless Genome Identified during Persistent Bovine Coronavirus Infection Is Associated with Attenuation of Gene Expression
Date Published: December 12, 2013 Publisher: Public Library of Science Author(s): Ting-Yung Ke, Wei-Yu Liao, Hung-Yi Wu, Volker Thiel. http://doi.org/10.1371/journal.pone.0082176 Abstract: The establishment of persistent viral infection is often associated with the selection of one or more mutant viruses. For example, it has been found that an intra-leader open reading frame (ORF) in genomic and … Continue reading
Research Article: Coronavirus Spike Protein Inhibits Host Cell Translation by Interaction with eIF3f
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Research Article: Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus
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Research Article: Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel
Date Published: July 10, 2009 Publisher: Public Library of Science Author(s): Konstantin Pervushin, Edward Tan, Krupakar Parthasarathy, Xin Lin, Feng Li Jiang, Dejie Yu, Ardcharaporn Vararattanavech, Tuck Wah Soong, Ding Xiang Liu, Jaume Torres, Ralph S. Baric. http://doi.org/10.1371/journal.ppat.1000511 Abstract: The envelope (E) protein from coronaviruses is a small polypeptide that contains at least one α-helical … Continue reading