Original Article: https://doi.org/10.1016/j.eclinm.2020.100642
- Fecal microbiota transplantation is when stool from a healthy donor is transferred into the colon of a sick person to introduce good bacteria.
- Fecal microbiota transplantation is effective for recurrent Clostridioides difficile infection.
- However, inconsistent effect rates and uncertain evidence levels have caused concerns.
- Clostridioides difficile infection occurs when an opportunistic bacteria infects the colon usually after taking antibiotics.
- Researchers aimed to establish the evidence of fecal microbiota transplantation for recurrent Clostridioides difficile infection.
- The clinical effect of a single fecal microbiota transplantation was 84 percent.
- The clinical effect of a repeat fecal microbiota transplantation was 91 percent.
- Fecal microbiota transplantation delivered by lower gastrointestinal endoscopy was the most effective of all delivery methods.
- Repeat fecal microbiota transplantation significantly increased the treatment effect.
- Data shows that the number of patients to be treated decreased after repeat fecal microbiota transplantation.
- Evidence supports fecal microbiota transplantation is effective in treating recurrent Clostridioides difficile infection however, its effect varies with the delivery method and the number of administration.
- The findings suggest that patients may benefit from advancing fecal microbiota transplantation to all cases of recurrent Clostridioides difficile infection.