Research Highlights: Evidence Shows Fecal Microbiota Transplantation is an Effective Treatment for C. Diff Infection

By fkfkrErbe, digital colorization by Christopher Pooley, both of USDA, ARS, EMU. – This image was released by the Agricultural Research Service, the research agency of the United States Department of Agriculture, with the ID K11077-1 (next)., Public Domain,

Original Article:

  • Fecal microbiota transplantation is when stool from a healthy donor is transferred into the colon of a sick person to introduce good bacteria.
  • Fecal microbiota transplantation is effective for recurrent Clostridioides difficile infection.
  • However, inconsistent effect rates and uncertain evidence levels have caused concerns.
  • Clostridioides difficile infection occurs when an opportunistic bacteria infects the colon usually after taking antibiotics.
  • Researchers aimed to establish the evidence of fecal microbiota transplantation for recurrent Clostridioides difficile infection.
  • The clinical effect of a single fecal microbiota transplantation was 84 percent.
  • The clinical effect of a repeat fecal microbiota transplantation was 91 percent.
  • Fecal microbiota transplantation delivered by lower gastrointestinal endoscopy was the most effective of all delivery methods.
  • Repeat fecal microbiota transplantation significantly increased the treatment effect.
  • Data shows that the number of patients to be treated decreased after repeat fecal microbiota transplantation.
  • Evidence supports fecal microbiota transplantation is effective in treating recurrent Clostridioides difficile infection however, its effect varies with the delivery method and the number of administration.
  • The findings suggest that patients may benefit from advancing fecal microbiota transplantation to all cases of recurrent Clostridioides difficile infection.


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