Excessive Exercise Linked to Mitochondrial Functional Impairment and Reduction of Glucose Tolerance
- Exercise can have a positive effect on metabolic health.
- Exercise can increase mitochondrial oxidative capacity and improve regulation of glucose.
- Exercise is initially encouraged to treat a number of metabolic diseases.
- However, the association between therapeutic benefits and excessive exercise has not been clear.
- Researchers used training model with increasing exercise level during a 4 week intervention.
- Glucose tolerance, mitochondrial function/dynamics, physical exercise capacity, and whole-body metabolism were monitored during the experiment.
- The result shows that mitochondrial function was reduced after the highest exercise level.
- The mitochondrial function reduction occurred simultaneously with the disruption in glucose tolerance and insulin production.
- Researchers also analyzed blood glucose in world-class endurance athletes and found that the glucose control was impaired.
Source:
Flockhart, M., Nilsson, L. C., Tais, S., Ekblom, B., Apró, W., & Larsen, F. J. (2021). Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell metabolism, S1550-4131(21)00102-9. Advance online publication. https://doi.org/10.1016/j.cmet.2021.02.017
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