Gut Bacteria Promote Therapy Resistant Prostate Cancer
- Androgens such as testosterone are important for male sexual and reproductive function.
- Androgens play a role in the growth of prostate cancer cells.
- Decreasing androgens by means of castration or hormone suppression is the current treatment for prostate cancer.
- Castration refers to the process of removing the testicles in males.
- The microbiota consist of microorganisms that inhabit a particular environment or location in or on the host.
- Microbiota contains different types of organisms which includes symbiotic, commensal, and pathogenic microorganisms.
- The role of the gut microbiota to the emergence of castration-resistance prostate cancer has not yet been addressed.
- Researchers discovered that deprivation of androgen in mice and humans encourages the expansion of some commensal microbiota that helps to begin the castration resistance.
- They found that when the body was deprived of androgens during the therapy, the gut microbiome could produce androgens from androgen precursors.
- When the gut microbiota was removed by antibiotic therapy, the emergence of castration resistance was delayed even when mice are immunodeficient.
- Fecal microbiota transplantation from castration-resistance prostate cancer mice and patients gave mice harboring prostate cancer resistant to castration.
- In contrast, the growth of tumor was controlled by fecal microbiota transplantation from patients with hormone-sensitive prostate cancer.
- Fecal microbiota transplantation, also known as a stool transplant, is the process of transferring fecal bacteria from a healthy individual into another individual.
- The results suggest that the commensal gut bacteria contributes to endocrine resistance in castration-resistance prostate cancer by providing an alternative source of androgens.
Sources:
Pernigoni, N., Zagato, E., Calcinotto, A., Troiani, M., Mestre, R. P., Calì, B., Attanasio, G., Troisi, J., Minini, M., Mosole, S., Revandkar, A., Pasquini, E., Elia, A. R., Bossi, D., Rinaldi, A., Rescigno, P., Flohr, P., Hunt, J., Neeb, A., Buroni, L., … Alimonti, A. (2021). Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis. Science (New York, N.Y.), 374(6564), 216–224. https://doi.org/10.1126/science.abf8403
