Research Highlights: Immune Memory to COVID-19 Virus Assessed for up to 8 Months after Infection

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Original Article:

  • Understanding SARS-CoV-2 immune memory is important for diagnostics and vaccine improvements.
  • The future course of the COVID-19 pandemic is likely dependent on our knowledge of the disease.
  • Researchers analyzed multiple compartments of circulating immune memory to SARS-CoV-2.
  • Number of samples analyzed: 254
  • Number of COVID-19 cases analyzed: 188
  • The study includes 43 samples taken from more than 6 months after infection.
  • IgG antibodies to the spike protein was relatively stable over 6 months.
  • Spike-specific memory B cells were higher in concentration at 6 months compared to 1st month during the start of symptoms.
  • SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months.
  • Researchers observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.


Dan, J. M., Mateus, J., Kato, Y., Hastie, K. M., Yu, E. D., Faliti, C. E., Grifoni, A., Ramirez, S. I., Haupt, S., Frazier, A., Nakao, C., Rayaprolu, V., Rawlings, S. A., Peters, B., Krammer, F., Simon, V., Saphire, E. O., Smith, D. M., Weiskopf, D., Sette, A., … Crotty, S. (2021). Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science (New York, N.Y.), eabf4063. Advance online publication.

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