Research Highlights: Inhibition of Prostaglandin-Degrading Enzyme Improves Aged Skeletal Muscle Mass, Strength, and Performance

Inhibition of Prostaglandin-Degrading Enzyme Improves Aged Skeletal Muscle Mass, Strength, and Performance

  • Sarcopenia is a condition characterized by age-related loss of skeletal muscle mass and function.
  • Currently, sarcopenia treatments are lacking.
  • Increase in enzyme that degrades prostaglandin is a hallmark of old tissues including skeletal muscle.
  • The reduction of prostaglandin signaling is the main contributor to the reduction of muscle mass in aged mice.
  • Researchers found that myofibers and interstitial cells within the old muscle produce the prostaglandin-degrading enzymes.
  • Inhibition of prostaglandin-degrading enzymes increases aged muscle mass, strength, and performance.
  • Inhibition of prostaglandin-degrading enzymes rejuvenated prostaglandin levels which increase mitochondrial function and damaged cell clean ups.
  • Inhibition of prostaglandin-degrading enzymes also decreases ubiquitin-proteasome pathways which is associate with protein degradation.
  • The study demonstrate how prostaglandin can counter muscle mass reduction.
  • The result suggests that prostaglandin-degrading enzymes is a potential therapeutic target to treat sarcopenia.


Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A., & Blau, H. M. (2020). Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. Science (New York, N.Y.), eabc8059. Advance online publication.

Research Summary: Calpain-6 Deficiency Promotes Skeletal Muscle Development and Regeneration

Abstract Calpains are Ca2+-dependent modulator Cys proteases that have a variety of functions in almost all eukaryotes. There are more than 10 well-conserved mammalian calpains, among which eutherian calpain-6 (CAPN6) is unique in that it has amino acid substitutions at the active-site Cys residue (to Lys in humans), strongly suggesting a loss of proteolytic activity. … Continue reading

Research Summary: Contribution of Human Muscle-Derived Cells to Skeletal Muscle Regeneration in Dystrophic Host Mice

ABSTRACT Background Stem cell transplantation is a promising potential therapy for muscular dystrophies, but for this purpose, the cells need to be systemically-deliverable, give rise to many muscle fibres and functionally reconstitute the satellite cell niche in the majority of the patient’s skeletal muscles. Human skeletal muscle-derived pericytes have been shown to form muscle fibres … Continue reading

Research Summary: Androgens Regulate Gene Expression in Avian Skeletal Muscles

ABSTRACT Circulating androgens in adult reproductively active male vertebrates influence a diversity of organ systems and thus are considered costly. Recently, we obtained evidence that androgen receptors (AR) are expressed in several skeletal muscles of three passeriform birds, the golden-collared manakin (Manacus vitellinus), zebra finch (Taenopygia guttata), and ochre-bellied flycatcher (Mionectes oleagieus). Because skeletal muscles … Continue reading

Leave a Reply