Original Source: https://doi.org/10.1016/j.cell.2020.08.048
- The primary function of the colon is to absorb fluids.
- The colon contains a large number of microorganisms including fungi, which are elevated near the end of the segment.
- The mucous membrane of the colon must regulate fluid influx to control absorption of metabolites from fungi.
- Fungal metabolites can be toxic to epithelial cells and lead to barrier dysfunction.
- The mechanism of the fluid influx regulation is still unclear.
- The study describe a mechanism by which the immune system is associated with quality checking the fluid absorption to avoid intoxication of epithelial cells of the colon.
- The mechanism relies on a number of distal colon macrophages attached to the epithelium.
- If the macrophages are not present, epithelial cells keep absorbing fluids containing fungal products.
- When epithelial cells absorb fungal products, they die and the epithelial barrier losses integrity.
- The data reveal an essential role of macrophages in the maintenance of colon-microbiota interactions in homeostasis.
Keywords: how fluids in colon are filtered, what cleans fluid in colon, colon fluid filtration, colon fluid absorption regulation, regulation of fluid in colon, role of macrophages in colon