Research Highlights: SARS-CoV-2 Variant More Difficult to be Killed by Immune Responses from Natural Infection or Vaccination
- The COVID-19 virus has caused more than 2 million deaths just over a year.
- Vaccines are being introduced to produce immune responses against the virus.
- The process of viral replication is prone to nucleic acid errors which can lead to mutant viruses and escape from antibody responses.
- Variant B.1.1.7 is dominating in the United Kingdom with increased transmission.
- The variant possesses 9 amino acid mutations in the spike protein which includes N501Y in the ACE2 interacting surface.
- Researchers examined how the variant evade antibody responses induced by COVID-19 natural viral infection and vaccination.
- The study mapped the impact of N501Y by structural and functional analyses of well-characterized monoclonal antibodies.
- The variant is more difficult to neutralize than the parental virus.
- Escape from monoclonal antibodies or antibody responses induced by natural infection or vaccination was not observed.
Supasa, P., Zhou, D., Dejnirattisai, W., Liu, C., Mentzer, A. J., Ginn, H. M., Zhao, Y., Duyvesteyn, H., Nutalai, R., Tuekprakhon, A., Wang, B., Paesen, G. C., Slon-Campos, J., López-Camacho, C., Hallis, B., Coombes, N., Bewley, K. R., Charlton, S., Walter, T. S., Barnes, E., … Screaton, G. R. (2021). Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera. Cell, S0092-8674(21)00222-1. Advance online publication. https://doi.org/10.1016/j.cell.2021.02.033
Highlights: SARS-CoV-2 E-Protein Structural Insight: A Potential Target for Vaccine Development and other Therapeutic Strategies
August 12, 2020 The outbreak of COVID-19 across the world has posed unparalleled and global challenges on multiple fronts. Most of the vaccine and drug development has focused on the spike proteins and viral RNA-polymerases and main protease for viral replication. Using the bioinformatics and structural modelling approach, the study modeled the structure of the … Continue reading
Original Article: https://doi.org/10.1126/science.abf4063 Understanding SARS-CoV-2 immune memory is important for diagnostics and vaccine improvements. The future course of the COVID-19 pandemic is likely dependent on our knowledge of the disease. Researchers analyzed multiple compartments of circulating immune memory to SARS-CoV-2. Number of samples analyzed: 254 Number of COVID-19 cases analyzed: 188 The study includes 43 … Continue reading
Research Highlights: Antigen-Specific Adaptive Immunity to Mild Covid-19 Infection and Correlations with Age and the Severity of the Disease
Original Article: https://doi.org/10.1016/j.cell.2020.09.038 The knowledge on the relationship between antigen-specific immune responses and COVID-19 disease severity is limited. Researchers examined all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and recovering subjects. Adaptive immunity usually occurs after exposure to an antigen either … Continue reading
Original Article: https://doi.org/10.1371/journal.pone.0241104 To accurately interpret COVID-19 surveys related to positive results, it is important to learn the knowledge of serum-IgG responses to COVID-19 virus with a better understanding of patients who do not develop antibody. The research aimed to describe serum-IgG responses to COVID-19 virus in a group of patients with both severe and … Continue reading
12 August 2020 In March 2020, the World Health Organization (WHO) declared a pandemic of coronavirus disease 2019 (COVID-19). The causative agent of COVID-19 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A vaccine is urgently needed due to the rising cases and deaths reported globally. This study reports the available safety, tolerability, and … Continue reading