Stem cell therapy after Praziquantel treatment may reduce liver damage in Schistosomiasis
Original Article: https://doi.org/10.1371/journal.pntd.0008635
- Mesenchymal stem cells have potential immunosuppressive and regenerative properties.
- Researchers investigated whether transplantation of adipose tissue-derived stem cells could be used to control the granulomatous reaction in the liver of mice infected with Schistosoma mansoni after Praziquantel treatment.
- Granulomatous reaction is a distinctive pattern of chronic inflammation characterized by nodular clustering of inflammatory cells, predominantly activated macrophages.
- Schistosoma mansoni is a species of trematode worm that parasitizes humans and that causes liver and gastrointestinal tract disease.
- Praziquantel is in a class of medications called anthelmintic and works by killing the worms.
- Schistosomiasis is the second most widespread parasitic disease in the world and is caused by the Schistosoma trematode.
- Schistosomiasis is characterized by a granulomatous reaction around parasite eggs trapped in the tissues.
- Schistosomiasis occurs when skin comes in contact with contaminated freshwater in which certain types of snails that carry the parasite are living.
- Schistosomiasis symptoms include rash or itchy skin, fever, chills, cough, and muscle aches.
- The liver is one of the most affected organs and can develop severe scarring of connective tissue.
- Praziquantel is the treatment for schistosomiasis and kills the adult worm.
- After the Praziquantel treatment, inflammation still persists around the eggs in the tissues.
- Mesenchymal stem cells have been extensively studied as an alternative therapy to repair tissues and to stop inflammation.
- Mesenchymal stem cells have the potential to differentiate in several cells types, and to interfere with immune responses.
- Researchers were motivated to investigate the use of mesenchymal stem cells extract from adipose tissue associated with Praziquantel to treat schistosomiasis.
- Mice were treated with Praziquantel followed by adipose tissue-derived stem cells injection.
- The results show significant reduction of the granulomas and normal levels of the enzyme alanine aminotransferase.
- Alanine aminotransferase test is a blood test used to check for liver damage.
- These results suggest that adipose tissue-derived stem cells has the potential to be used as a new therapeutic approach to control inflammation following infection by S. mansoni or liver disorders.
- Further studies using the chronic model of schistosomiasis are required to confirm using adipose tissue-derived stem cells for schistosomiasis therapy.
Miranda VHS, Gomes TR, Eller DE, Ferraz LdCN, Chaves AT, Bicalho KA, et al. (2020) Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment. PLoS Negl Trop Dis 14(8): e0008635. https://doi.org/10.1371/journal.pntd.0008635