Vitamin B12 May Alleviate Parkinson’s Disease
- Cobalamin, also known as Vitamin B12, is a water-soluble vitamin associated with metabolism.
- Vitamin B12 plays an important role in the normal functioning of the nervous system.
- Myelin works as an insulator of nerve cell axon to increase the rate of electrical impulses.
- Severe vitamin B12 deficiencies have been associated to damage of learning and memory ability, cognitive decline, and neurological diseases.
- Alpha-synuclein is a protein with unknown function usually found in neural tissue making up as much as 1% of all proteins in the cytosol of brain cells.
- Alpha-synuclein is predominantly expressed in the neocortex, hippocampus, substantia nigra, thalamus, and cerebellum.
- Defective and clustering of alpha-synuclein into insoluble fibrils is linked with the beginning and progression of Parkinson’s disease.
- Parkinson’s disease is a progressive neurological movement disorder which affects tens of millions of elderly patients around the world.
- One topic of intense research is the development of new inhibitory drugs that can obstruct the clustering of alpha-synuclein.
- Researchers analyzed the inhibitory capability of vitamin B12 against the development of fibrils and cytotoxicity of alpha-synuclein.
- Results suggest that vitamin B12 could inhibit alpha-synuclein fibril development in a dose-dependent manner.
- Data suggest that vitamin B12 delays the conversion of alpha-synuclein into β-sheet rich structures.
- As a result, vitamin B12 significantly reduced the cytotoxicity of alpha-synuclein clusters.
- Additionally, vitamin B12 was found to disassemble preexisting mature alpha-synuclein fibrils and reduce the subsequent cytotoxicity.
- The study provides a comprehensive understanding of the inhibitory capability of vitamin B12 on alpha-synuclein fibril development and identify an important nutrient source that possesses significant potential to be developed as a new functional food ingredient to help relieve Parkinson’s disease.
Jia, L., , Wang, Y., , Wei, W., , Zhao, W., , Lu, F., , & Liu, F., (2019). Vitamin B12 inhibits α-synuclein fibrillogenesis and protects against amyloid-induced cytotoxicity. Food & function, 10(5), 2861–2870. https://doi.org/10.1039/c8fo02471e
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