Microarrays are the main technology for large-scale transcriptional gene expression profiling, but the large bodies of data available in public databases are not useful due to the large heterogeneity. There are several initiatives that attempt to bundle these data into expression compendia, but such resources for bacterial organisms are scarce and limited to integration of experiments from the same platform or to indirect integration of per experiment analysis results.
We have constructed comprehensive organism-specific cross-platform expression compendia for three bacterial model organisms (
We have created cross-platform expression compendia for several bacterial organisms and developed a complementary access port COLOMBOS, that also serves as a convenient expression analysis tool to extract useful biological information. This work is relevant to a large community of microbiologists by facilitating the use of publicly available microarray experiments to support their research.
Publisher: Public Library of Science
Date Published: 14-July-2011
Author(s): Engelen K., Fu Q., Meysman P., Sánchez-Rodríguez A., De Smet R., Lemmens K., Fierro A., Marchal K.