Research Summary: Correlation of Viral Loads with HCV Genotypes: Higher Levels of Virus Were Revealed among Blood Donors Infected with 6a Strains



Both HCV genotypes and viral loads are predictors of therapeutic outcomes among patients treated with α-interferon plus ribavirin; however, such correlation has only been studied for genotypes 1, 2, and 3 but not for genotype 6.


299 voluntary blood donors were recruited who were HCV viremic. Their mean age was 31.8; the male/female ratio was 3.82 (225/59). The viral loads of HCV were measured using the COBAS AmpliPrep/COBAS TaqMan test (CAP/CTM) while HCV genotypes were determined by direct sequencing the partial NS5B region. HCV genotypes 1, 2, 3, and 6 were determined in 48.9%, 8.7%, 12.3%, and 30.1% of the donors, respectively, and the levels of mean viral loads in genotype 1 and 6 significantly higher than that of 2 and 3 (P<0.001). As a whole, the viral loads in male donors were higher than in female (P = 0.006). Moreover, the donors’ gender and HCV genotypes are independently correlated with the measured viral loads.


HCV genotype 1 and 6 had significantly higher viral loads than genotype 2 and 3.


Publisher: Public Library of Science

Date Published: 17-December-2012

Author(s): Rong X., Lu L., Wang J., Xiong H., Huang J., Chen J., Huang K., Xu R., Wang M., Zhang X., Guo T., Liu Y., Gao G., Fu Y., Nelson K.


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