Acquisition of a final shape and size during organ development requires a
regulated program of growth and patterning controlled by a complex genetic
network of signalling molecules that must be coordinated to provide positional
information to each cell within the corresponding organ or tissue. The mechanism
by which all these signals are coordinated to yield a final response is not well
understood. Here, I have characterized the
of the human TGF-β Inducible Early Gene 1 (dTIEG). TIEG are zinc-finger
proteins that belong to the Krüppel-like factor (KLF) family and were
initially identified in human osteoblasts and pancreatic tumor cells for the
ability to enhance TGF-β response. Using the developing wing of
function has been studied in the control of cell proliferation and patterning.
These results show that dTIEG can modulate Dpp signalling. Furthermore, dTIEG
also regulates the activity of JAK/STAT pathway suggesting a conserved role of
TIEG proteins as positive regulators of TGF-β signalling and as mediators of
the crosstalk between signalling pathways acting in a same cellular context.
Publisher: Public Library of Science
Date Published: 8-April-2011
Author(s): Rodriguez I.