Accumulated evidences have shown that vascular risk factors, e.g., hypertension, diabetes mellitus and hyperlipidemia, may be related to the risk of dementia. This study investigated the association between genetic polymorphisms of a vascular susceptibility gene, Ninjurin2
A total of 275 Alzheimer’s disease (AD) patients and 119 vascular dementia (VaD) patients aged 50 or older were recruited from three teaching hospitals from 2007 to 2010. Healthy controls (n = 423) with the same age of cases were recruited from the health checkup and volunteers worked at the hospital during the same time period. Five common (frequency >5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) in
Homozygosity of two
Inherited polymorphisms of the vascular susceptibility gene
Publisher: Public Library of Science
Date Published: 6-June-2011
Author(s): Lin K., Chen S., Lai L., Huang Y., Chen J., Chen T., Sun Y., Wen L., Yip P., Chu Y., Chen W., Chen Y.