Background & Aims
Recent studies reported a role for more than 70 genes or loci in the susceptibility to Crohn’s disease (CD). However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and phenotypes for the main 53 CD-associated polymorphisms.
A cohort of 798 CD patients with a median follow up of 7 years was recruited by tertiary adult and paediatric gastroenterological centres. A detailed phenotypic description of the disease was recorded, including clinical presentation, response to treatments and complications. The participants were genotyped for 53 CD-associated variants previously reported in the literature and correlations with clinical sub-phenotypes were searched for. A replication cohort consisting of 722 CD patients was used to further explore the putative associations.
It is not recommended to genotype the studied polymorphisms in routine practice.
Publisher: Public Library of Science
Date Published: 27-December-2012
Author(s): Jung C., Colombel J., Lemann M., Beaugerie L., Allez M., Cosnes J., Vernier-Massouille G., Gornet J., Gendre J., Cezard J., Ruemmele F., Turck D., Merlin F., Zouali H., Libersa C., Dieudé P., Soufir N., Thomas G., Hugot J.