Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite this, patients with these tumors are treated in a similar fashion as all other ovarian cancers. Previous genomic analysis has suggested that clear cell cancers represent a unique tumor subtype. Here we generated the first whole genomic expression profiling using epithelial component of clear cell ovarian cancers and normal ovarian surface specimens isolated by laser capture microdissection. All the arrays were analyzed using BRB ArrayTools and PathwayStudio software to identify the signaling pathways. Identified pathways validated using serous, clear cell cancer cell lines and RNAi technology.
Publisher: Public Library of Science
Date Published: 6-July-2011
Author(s): Stany M., Vathipadiekal V., Ozbun L., Stone R., Mok S., Xue H., Kagami T., Wang Y., McAlpine J., Bowtell D., Gout P., Miller D., Gilks C., Huntsman D., Ellard S., Wang Y., Vivas-Mejia P., Lopez-Berestein G., Sood A., Birrer M.