Research Summary: Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice

ABSTRACT

In neurodegenerative disorders, abnormally hyperphosphorylated and aggregated tau accumulates intracellularly, a mechanism which is thought to induce neuronal cell death. Methylene blue, a type of phenothiazine, has been reported to inhibit tau aggregation in vitro. However, the effect of methylene blue in vivo has remained unknown. Therefore, we examined whether methylene blue suppresses abnormal tau accumulation using P301L tau transgenic mice. At 8 to 11 months of age, these mice were orally administered methylene blue for 5 months. Subsequent results of Western blotting analysis revealed that this agent reduced detergent-insoluble phospho-tau. Methylene blue may have potential as a drug candidate for the treatment of tauopathy.

____________________________

Publisher: Public Library of Science

Date Published: 20-December-2012

Author(s): Hosokawa M., Arai T., Masuda-Suzukake M., Nonaka T., Yamashita M., Akiyama H., Hasegawa M.

Link: https://doi.org/10.1371/journal.pone.0052389

Leave a Reply

Your email address will not be published. Required fields are marked *