Research Summary: Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders

ABSTRACT

Background

Accumulating evidence suggests that dysregulation of the immune system is
involved in the pathophysiology of autism spectrum disorders (ASD). The aim
of the study was to explore immunological markers in peripheral plasma
samples from non-medicated subjects with high-functioning ASD.


Methodology/Principal Findings

A multiplex assay for cytokines and chemokines was applied to plasma samples
from male subjects with high-functioning ASD (n = 28)
and matched controls (n = 28). Among a total of 48
analytes examined, the plasma concentrations of IL-1β, IL-1RA, IL-5,
IL-8, IL-12(p70), IL-13, IL-17 and GRO-α were significantly higher in
subjects with ASD compared with the corresponding values of matched controls
after correction for multiple comparisons.


Conclusion/Significance

The results suggest that abnormal immune responses as assessed by multiplex
analysis of cytokines may serve as one of the biological
trait markers for ASD.

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Publisher: Public Library of Science

Date Published: 27-May-2011

Author(s): Suzuki K., Matsuzaki H., Iwata K., Kameno Y., Shimmura C., Kawai S., Yoshihara Y., Wakuda T., Takebayashi K., Takagai S., Matsumoto K., Tsuchiya K., Iwata Y., Nakamura K., Tsujii M., Sugiyama T., Mori N.

Link: https://doi.org/10.1371/journal.pone.0020470

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