Fat mass and obesity (
To investigate whether
Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects.
FTO rs9939609 was associated with higher body mass index (BMI), waist circumference (WC) and obesity (P<0.05 for all). A similar, but not significant trend was found for MC4R rs17782313. Their additive effects (aggregate score) were significant and we observed a 7% per-allele increase of being obese (OR = 1.07; 95%CI 1.01–1.13). We found relevant statistical interactions (P<0.05) with PA. So, in active individuals, the associations with higher BMI, WC or obesity were not detected. A biological (non-statistical) interaction between AdMedDiet and rs9939609 and the aggregate score was found. Greater AdMedDiet in individuals carrying 4 or 3-risk alleles counterbalanced their genetic predisposition, exhibiting similar BMI (P = 0.502) than individuals with no risk alleles and lower AdMedDiet. They also had lower BMI (P = 0.021) than their counterparts with low AdMedDiet. We did not find any consistent association with energy or macronutrients, but found a novel association between these polymorphisms and lower alcohol consumption in variant-allele carriers (B+/−SE: −0.57+/−0.16 g/d per-score-allele; P = 0.001).
Statistical and biological interactions with PA and diet modulate the effects of
Publisher: Public Library of Science
Date Published: 21-December-2012
Author(s): Corella D., Ortega-Azorín C., Sorlí J., Covas M., Carrasco P., Salas-Salvadó J., Martínez-González M., Arós F., Lapetra J., Serra-Majem L., Lamuela-Raventos R., Gómez-Gracia E., Fiol M., Pintó X., Ros E., Martí A., Coltell O., Ordovás J., Estruch R.