THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using
Publisher: Public Library of Science
Date Published: 20-December-2012
Author(s): Castellano-Pozo M., García-Muse T., Aguilera A.