Research Summary: Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues


The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity.


Publisher: Public Library of Science

Date Published: 20-December-2012

Author(s): Nelissen J., Nuyts K., De Zotti M., Lavigne R., Lamberigts C., De Borggraeve W.


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